Subscribe Button 1

High-Precision Microscope Focusing Stage For Super Resolution Microscopy

ALIO Industries has recently released a high-precision focusing stage, the AI-VC-600-Z-SCB, which is critical in such applications as Super Resolution Microscopy, Atomic Force Microscopy, surface metrology, and industrial manufacturing and inspection applications. The precision focusing stage provides nanometer-level resolution and an extremely fast millisecond-range response.

Bill Hennessey, President of ALIO Industries says, “While microscopes have long been invaluable tools in biological research, a key drawback has been resolution limitations, making it impossible to use them as a tool to examine sub-cellular or sub-organelle details. Recent advances in fluorescence microscopy, a type of light microscopy in which one wavelength of light is absorbed and another omitted, allows super-resolution microscopy to observe living sub-cellular structures and activities.”

ALIO’s AI-VC-600-Z-SCB high-precision focusing stage, when used in such applications, provides closed loop precision and extremely fast response to achieve sub-atomic resolution, critical in high resolution microscopy. The result is higher quality images at a much faster rate of speed. With a 6 mm travel range and a 500g payload, the AI-VC-600-Z-SCB can achieve 4G 100% S-curve peak acceleration (which is equivalent to 2G trapezoidal acceleration) and 300mm/sec with 5nm resolution and can achieve 1nm resolution by reducing the speed capability to 30mm/sec.

Hennessey continues, “The AI-VC-600-Z-SCB stage facilitates many applications at the bleeding edge of life science research, including DNA sequencing to stimulate the drive towards personalized medicine. ALIO high-precision microscope focusing stages are also a game changer in the field of digital pathology. The key to success in these types of applications is image capture at a high rate of speed with absolute focus on nanometer-level precision. The applications further require that the motion control solution must combine smoothness (meaning highest possible image resolution), flatness (controlling the z-axis meaning maintenance of focus), and straightness (reducing overlap between scanning “passes” and increasing throughput).”

For more information: